Symptoms

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🧠 Nervous System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Headache	Pain in the head or scalp	Due to tension (muscle contraction), increased intracranial pressure, migraine (vasodilation + neurogenic inflammation), or inflammation of meninges
☐	Dizziness	Lightheadedness or feeling faint	Decreased cerebral perfusion, anemia, hypotension, vestibular imbalance
☐	Vertigo	Illusion of movement or spinning	Disturbance in vestibular system – inner ear, vestibular nerve, or cerebellum
☐	Seizure	Sudden, uncontrolled brain activity	Abnormal neuronal firing due to electrolyte imbalance, tumor, trauma, infection, or epilepsy
☐	Syncope	Temporary loss of consciousness	Global cerebral hypoperfusion caused by cardiac, neurogenic, or orthostatic causes
☐	Paresthesia	Tingling, prickling sensation	Due to nerve injury, ischemia, or peripheral neuropathy (e.g., diabetes)
☐	Weakness	Loss of muscle strength	May be due to stroke (UMN lesion), neuropathy, myopathy, or NMJ disorders
☐	Ataxia	Loss of coordination	Damage to cerebellum or dorsal columns
☐	Aphasia	Inability to speak or comprehend language	Lesions in dominant hemisphere (Broca’s, Wernicke’s areas)

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❤️ Cardiovascular System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Chest Pain	Discomfort in chest	Due to ischemia (angina, MI), pericarditis, aortic dissection
☐	Palpitations	Awareness of heartbeat	Arrhythmia, anxiety, caffeine, thyrotoxicosis
☐	Dyspnea	Shortness of breath	Pulmonary congestion, LV failure, low cardiac output
☐	Orthopnea	Breathlessness on lying down	Pulmonary venous return increases → fluid backs up into lungs
☐	PND	Sudden night-time breathlessness	Reabsorption of interstitial fluid in lungs during sleep
☐	Pedal Edema	Swelling of legs/feet	Right heart failure, hypoalbuminemia, renal causes
☐	Cyanosis	Bluish discoloration of skin	Due to deoxygenated hemoglobin > 5 g/dL in capillaries
☐	Syncope	Sudden loss of consciousness	Drop in cerebral perfusion due to arrhythmias, valve disease

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🫁 Respiratory System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Cough	Sudden forceful expulsion of air	Irritation of airways from infection, allergens, or secretions
☐	Sputum	Expectoration  of mucus from lungs	Produced in response to inflammation/infection
☐	Hemoptysis	Coughing up blood	Bronchial vessel rupture due to TB, cancer, bronchiectasis
☐	Wheeze	High-pitched breath sound	Bronchial narrowing in asthma or COPD
☐	Stridor	Harsh inspiratory sound	Upper airway obstruction (e.g., foreign body, croup)
☐	Dyspnea	Difficulty breathing	Reduced oxygen exchange or airflow obstruction
☐	Pleuritic chest pain	Sharp pain on deep breathing	Inflammation of pleura (pleuritis, PE)

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🍽️ Gastrointestinal System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Nausea/Vomiting	Urge or act of expelling gastric contents	Stimulated by vomiting center (toxins, GI irritation, ICP)
☐	Anorexia	Loss of appetite	Cytokine response in infection, malignancy, or GI irritation
☐	Abdominal Pain	Pain in the abdomen	Stretch, inflammation, or ischemia of viscera
☐	Diarrhea	Frequent, loose stools	Increased intestinal motility, secretions (infection, IBS)
☐	Constipation	Infrequent, hard stools	↓ Motility, dehydration, hypothyroidism, obstruction
☐	Dysphagia	Difficulty in swallowing	Obstruction, neurological lesion, esophageal motility disorder
☐	Heartburn	Burning chest pain	Acid reflux irritating esophagus (GERD)
☐	GI bleeding	Blood in vomit or stool	Ulcers, varices, carcinoma, hemorrhoids

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🧬 Renal / Genitourinary System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Dysuria	Pain during urination	UTI, urethritis, inflammation of mucosa
☐	Frequency	Increased urge to urinate	Bladder irritation or reduced capacity
☐	Urgency	Sudden strong urge to urinate	Detrusor instability, cystitis
☐	Hematuria	Blood in urine	Glomerular damage, stones, cancer
☐	Oliguria	<400 mL/day urine output	AKI, dehydration, obstruction
☐	Incontinence	Involuntary urine leakage	Stress, overflow, neurogenic bladder
☐	Flank pain	Pain in loin area	Stone, pyelonephritis, trauma

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🧠 Endocrine System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Weight Loss	Unintended loss of weight	↑ Metabolism (hyperthyroid), malignancy, DM
☐	Weight Gain	Unintended gain	Hypothyroidism, Cushing’s syndrome
☐	Polyuria	Excess urination	Osmotic diuresis in DM, ↓ ADH in DI
☐	Polydipsia	Excess thirst	Dehydration due to polyuria
☐	Fatigue	Lack of energy	Hypothyroid, Addison’s, anemia
☐	Cold Intolerance	Sensitivity to cold	↓ Basal metabolic rate in hypothyroid
☐	Heat Intolerance	Overheating	↑ BMR in hyperthyroid

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🦴 Musculoskeletal System

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Joint Pain (Arthralgia)	Pain in joints	Inflammation (RA), cartilage wear (OA)
☐	Morning stiffness	Stiffness after waking	RA, spondyloarthritis (inflammatory)
☐	Muscle Cramps	Painful spasm of muscle	Electrolyte imbalance (low Ca/K), overuse
☐	Back Pain	Pain in lumbar region	Disc herniation, strain, spinal stenosis

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🧠 Psychiatric Symptoms

✅	Symptom	Definition	Why It Happens (Pathogenesis)
☐	Insomnia	Inability to sleep	Anxiety, depression, stress, stimulant use
☐	Depression	Persistent low mood and energy	Neurotransmitter imbalance (low serotonin)
☐	Anxiety	Excessive worry or fear	Overactive sympathetic system; GABA imbalance
☐	Delusions	False belief not based on reality	Psychotic disorders like schizophrenia
☐	Hallucinations	Perception without stimulus	Dopamine excess (schizophrenia, drugs)

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